For their delayed home opener, the Indians elected to wear their blue road jerseys with “Cleveland” on the front as a unified statement of solidarity for minorities as the team contemplates a name change.
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| Michigan vs Milwaukee | |
| Type: Moneyline - Status: OPEN | |
| Michigan | -1000 |
| Milwaukee | +550 |
| Kent State vs Wright State | |
| Type: Runline - Status: OPEN | |
| Kent State | -110 |
| Wright State | -120 |
| Northwestern vs Valparaiso | |
| Type: Runline - Status: OPEN | |
| Northwestern | -135 |
| Valparaiso | +105 |
| Wake Forest vs High Point | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Pittsburgh Panthers vs Penn State | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Panthers | -145 |
| Penn State | +110 |
| Connecticut vs Northeastern (#25) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Buffalo Bisons vs Worcester Red Sox | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| Syracuse Mets vs Lehigh Valley IronPigs | |
| Type: Moneyline - Status: OPEN | |
| Syracuse Mets | -120 |
| Lehigh Valley IronPigs | -110 |
| Scranton Wilkes-Barre RailRiders vs Toledo Mud Hens | |
| Type: Moneyline - Status: OPEN | |
| Scranton Wilkes-Barre RailRiders | -145 |
| Toledo Mud Hens | +110 |
| Rochester Red Wings vs Durham Bulls | |
| Type: Moneyline - Status: OPEN | |
| Rochester Red Wings | +150 |
| Durham Bulls | -200 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Milwaukee Brewers - 1H | -125 |
| Cleveland Guardians - 1H | -105 |
| South Carolina vs Winthrop | |
| Type: Moneyline - Status: OPEN | |
| South Carolina | -200 |
| Winthrop | +150 |
| Indianapolis Indians vs Louisville Bats | |
| Type: Moneyline - Status: OPEN | |
| Indianapolis Indians | -145 |
| Louisville Bats | +110 |
| Norfolk Tides vs Jacksonville Jumbo Shrimp | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | -220 |
| Detroit Tigers | +180 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -290 |
| Over - 1I | +210 |
| Kennesaw State vs Georgia Southern | |
| Type: Moneyline - Status: OPEN | |
| Kennesaw State | -120 |
| Georgia Southern | -110 |
| Wichita State vs Oral Roberts | |
| Type: Runline - Status: OPEN | |
| Wichita State | -145 |
| Oral Roberts | +110 |
| Sugar Land Space Cowboys vs Reno Aces | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | -150 |
| Toronto Blue Jays - 1H | +115 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| Atlanta Braves vs Washington Nationals | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| UT Rio Grande Valley vs Texas State | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Omaha Storm Chasers vs Columbus Clippers | |
| Type: Moneyline - Status: OPEN | |
| Omaha Storm Chasers | -115 |
| Columbus Clippers | -115 |
| Iowa Cubs vs St. Paul Saints | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs | -120 |
| Miami Marlins | +100 |
| Memphis Redbirds vs Nashville Sounds | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Shandong Blue Whale vs Shanghai Eagles | |
| Type: Runline - Status: OPEN | |
| Shandong Blue Whale | -105 |
| Shanghai Eagles | -125 |
| Chongqing vs Tianjin University of Sport | |
| Type: Moneyline - Status: OPEN | |
| Chongqing | -110 |
| Tianjin University of Sport | -110 |
| BYU vs Utah | |
| Type: Runline - Status: OPEN | |
| BYU | +120 |
| Utah | -160 |
| Texas Rangers vs Colorado Rockies | |
| Type: Runline - Status: OPEN | |
| Texas Rangers | -115 |
| Colorado Rockies | -105 |
| Round Rock Express vs Oklahoma City Dodgers | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | +110 |
| Houston Astros - 1H | -145 |
| Oregon State (#7) vs Portland | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Albuquerque Isotopes vs Tacoma Rainiers | |
| Type: Moneyline - Status: OPEN | |
| Tacoma Rainiers | -105 |
| Albuquerque Isotopes | -125 |
| Cal Baptist vs Long Beach State | |
| Type: Runline - Status: OPEN | |
| Cal Baptist | +110 |
| Long Beach State | -145 |
| Gonzaga vs Washington State | |
| Type: Runline - Status: OPEN | |
| Gonzaga | -120 |
| Washington State | -110 |
| Pericos de Puebla vs Leones de Yucatan | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -130 |
| Conspiradores de Queretaro vs Tigres de Quintana Roo | |
| Type: Runline - Status: OPEN | |
| Conspiradores de Queretaro | -110 |
| Tigres de Quintana Roo | -130 |
| Arizona State vs Grand Canyon | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Algodoneros del Unión Laguna vs Rieleros de Aguascalientes | |
| Type: Moneyline - Status: OPEN | |
| Algodoneros del Unión Laguna | -140 |
| Rieleros de Aguascalientes | +100 |
| Sultanes de Monterrey vs Dorados de Chihuahua | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -140 |
| Piratas de Campeche vs El Aguila de Veracruz | |
| Type: Moneyline - Status: OPEN | |
| Piratas de Campeche | +100 |
| El Aguila de Veracruz | -140 |
| Bravos de Leon vs Guerreros de Oaxaca | |
| Type: Moneyline - Status: OPEN | |
| Bravos de Leon | +120 |
| Guerreros de Oaxaca | -170 |
| Saraperos de Saltillo vs Tecolotes de los Dos Laredos | |
| Type: Total - Status: OPEN | |
| Under | -130 |
| Over | -110 |
| Las Vegas Aviators vs El Paso Chihuahuas | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Generales De Durango vs Charros de Jalisco | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -120 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -120 |
| Seattle Mariners - 1I | -110 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1I | -185 |
| Los Angeles Angels - 1I | +140 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +145 |
| San Francisco Giants | -170 |
| Acereros de Monclova vs Toros de Tijuana | |
| Type: Moneyline - Status: OPEN | |
| Toros de Tijuana | -125 |
| Acereros de Monclova | -115 |
| Los Angeles Dodgers vs Athletics | |
| Type: Moneyline - Status: OPEN | |
| Athletics | +168 |
| Los Angeles Dodgers | -206 |
| Hokkaido Nippon-Ham Fighters vs Orix Buffaloes | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Tohoku Rakuten Golden Eagles vs Chiba Lotte Marines | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Hebei vs Fujian | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Tianjin Lion vs Jiangsu Horse | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Fukuoka SoftBank Hawks vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Fukuoka SoftBank Hawks | -130 |
| Saitama Seibu Lions | +100 |
| Chunichi Dragons vs Tokyo Yakult Swallows | |
| Type: Runline - Status: OPEN | |
| Chunichi Dragons | +230 |
| Tokyo Yakult Swallows | -325 |
| Hiroshima Toyo Carp vs Yomiuri Giants | |
| Type: Runline - Status: OPEN | |
| Hiroshima Toyo Carp | -165 |
| Yomiuri Giants | +125 |
| Hanwha Eagles vs Doosan Bears | |
| Type: Moneyline - Status: OPEN | |
| Hanwha Eagles | -105 |
| Doosan Bears | -125 |
| Kia Tigers vs Lotte Giants | |
| Type: Runline - Status: OPEN | |
| Kia Tigers | +115 |
| Lotte Giants | -150 |
| LG Twins vs Kiwoom Heroes | |
| Type: Moneyline - Status: OPEN | |
| LG Twins | -155 |
| Kiwoom Heroes | +120 |
| Samsung Lions vs KT Wiz | |
| Type: Moneyline - Status: OPEN | |
| Samsung Lions | -175 |
| KT Wiz | +135 |
| SSG Landers vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Fubon Guardians vs TSG Hawks | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| Wei Chuan Dragons vs CTBC Brothers | |
| Type: Moneyline - Status: OPEN | |
| Wei Chuan Dragons | -155 |
| CTBC Brothers | +120 |
| Rakuten Monkeys vs Uni-Lions | |
| Type: Moneyline - Status: OPEN | |
| Rakuten Monkeys | -120 |
| Uni-Lions | -110 |
