Cardinals right-hander Miles Mikolas will be the team’s starter for Opening Day in Los Angeles against the Dodgers on March 28.
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| Washington Nationals vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals | -110 |
| Washington Nationals | -110 |
| Pittsburgh Pirates vs Atlanta Braves | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves - 1H | -105 |
| Pittsburgh Pirates - 1H | -125 |
| Athletics vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -125 |
| Athletics - 1I | -105 |
| Tampa Bay Rays vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -130 |
| Under - 1H | +100 |
| Detroit Tigers vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Texas Rangers | +145 |
| Detroit Tigers | -170 |
| Cleveland Guardians vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -125 |
| Cleveland Guardians | +105 |
| Chicago White Sox vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Kansas City Royals vs Boston Red Sox | |
| Type: Moneyline - Status: OPEN | |
| Boston Red Sox | -116 |
| Kansas City Royals | -104 |
| Houston Astros vs Cincinnati Reds | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| New York Mets vs Chicago Cubs | |
| Type: Total - Status: OPEN | |
| Under - 1H | -115 |
| Over - 1H | -115 |
| Minnesota Twins vs San Francisco Giants | |
| Type: Total - Status: OPEN | |
| Over - 1H | -125 |
| Under - 1H | -105 |
| Arizona Diamondbacks vs Los Angeles Dodgers | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks - 1H | +110 |
| Los Angeles Dodgers - 1H | -145 |
| Colorado Rockies vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | -185 |
| Colorado Rockies - 1H | +140 |
| Los Angeles Angels vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels - 1H | +105 |
| Baltimore Orioles - 1H | -135 |
| Seattle Mariners vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Toronto Blue Jays - 1H | +100 |
| Seattle Mariners - 1H | -130 |
