Mets second baseman Robinson Cano previously tested positive for PEDs in 2018 with the Mariners. His second positive test will cost him the entire 2021 season.
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| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | -135 |
| Hanshin Tigers | +105 |
| Chiba Lotte Marines vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Chiba Lotte Marines | -205 |
| Saitama Seibu Lions | +155 |
| Fukuoka SoftBank Hawks vs Orix Buffaloes | |
| Type: Runline - Status: OPEN | |
| Fukuoka SoftBank Hawks | +190 |
| Orix Buffaloes | -260 |
| Hokkaido Nippon-Ham Fighters vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +185 |
| Tohoku Rakuten Golden Eagles | -250 |
| Hiroshima Toyo Carp vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Hiroshima Toyo Carp | -165 |
| Tokyo Yakult Swallows | +125 |
| Yomiuri Giants vs Chunichi Dragons | |
| Type: Runline - Status: OPEN | |
| Yomiuri Giants | +120 |
| Chunichi Dragons | -155 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| KT Wiz vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| LG Twins vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Moneyline - Status: OPEN | |
| Lotte Giants | -120 |
| Hanwha Eagles | -110 |
| Samsung Lions vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +115 |
| Samsung Lions | -150 |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +125 |
| Atlanta Braves - 1H | -165 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees | -150 |
| Cleveland Guardians | +126 |
| Detroit Tigers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | +120 |
| Detroit Tigers - 1H | -160 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Miami Marlins | +165 |
| Cincinnati Reds | -195 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Boston Red Sox vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Seattle Mariners - 1H | -120 |
| Boston Red Sox - 1H | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1I | -110 |
| Baltimore Orioles - 1I | -120 |
