The first time the Cubs and Pirates met this season, the Bucs came from behind three days in a row to sweep the series at Wrigley Field. The Cubs ensured there would be no comeback Monday night, running up a big lead in the first two innings and cruising to a 14-3 win at PNC Park.
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| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians - 1H | -125 |
| Milwaukee Brewers - 1H | -105 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: SUSPENDED | |
| Boston Red Sox - 1I | |
| Detroit Tigers - 1I | |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | +120 |
| Philadelphia Phillies - 1I | -160 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| New York Mets | +165 |
| Pittsburgh Pirates | -195 |
| Atlanta Braves vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves | +115 |
| Washington Nationals | -135 |
| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| Houston Astros vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | +100 |
| Los Angeles Angels - 1H | -130 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners - 1H | +105 |
| New York Yankees - 1H | -135 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | -225 |
| San Francisco Giants | +185 |
