The team with the American League’s best record will decide whether it wants an extra day off during its first-round playoff series. In recent years, one of the four postseason series had an extra off day between Games 1 and 2, and it alternated leagues in the series that didn’t involve a wild-card team.
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| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -195 |
| Baltimore Orioles | +165 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| Philadelphia Phillies | +115 |
| St. Louis Cardinals | -135 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Arizona Diamondbacks | -109 |
| San Francisco Giants | -111 |
| Seattle Mariners vs New York Yankees | |
| Type: Total - Status: OPEN | |
| Over - 1H | -115 |
| Under - 1H | -115 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under | +105 |
| Over | -125 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +185 |
| New York Mets - 1H | -250 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -230 |
| Chicago White Sox | +190 |
| Atlanta Braves vs Washington Nationals | |
| Type: Moneyline - Status: OPEN | |
| Atlanta Braves - 1I | -150 |
| Washington Nationals - 1I | +115 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs - 1H | +100 |
| Miami Marlins - 1H | -130 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals | +114 |
| Houston Astros | -136 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1I | +210 |
| Under - 1I | -290 |
| Los Angeles Dodgers vs Athletics | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
