The defending champion’s biggest offseason move was to get the right-handed pitcher, who has looked good in his first three starts.
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| Chicago Cubs vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs - 1H | +100 |
| Philadelphia Phillies - 1H | -130 |
| Detroit Tigers vs Baltimore Orioles | |
| Type: Runline - Status: SUSPENDED | |
| Baltimore Orioles - 1I | |
| Detroit Tigers - 1I | |
| Washington Nationals vs New York Mets | |
| Type: Moneyline - Status: OPEN | |
| New York Mets - 1H | -160 |
| Washington Nationals - 1H | +120 |
| New York Yankees vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Toronto Blue Jays - 1I | +110 |
| New York Yankees - 1I | -145 |
| Cleveland Guardians vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | +145 |
| Cleveland Guardians | -170 |
| Kansas City Royals vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Houston Astros | +135 |
| Kansas City Royals | -160 |
| Minnesota Twins vs Los Angeles Angels | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| St. Louis Cardinals vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| St. Louis Cardinals | +165 |
| Milwaukee Brewers | -195 |
| Colorado Rockies vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -145 |
| Colorado Rockies | +122 |
| San Diego Padres vs Tampa Bay Rays | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Seattle Mariners vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners | -290 |
| Miami Marlins | +230 |
| Arizona Diamondbacks vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Athletics vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Los Angeles Dodgers vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| Los Angeles Dodgers | +110 |
| Pittsburgh Pirates | -130 |
| San Francisco Giants vs Texas Rangers | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
