The Red Sox and the Astros, who combined to win 211 games in the regular season en route to posting the top two records in the Major Leagues, will square off in the American League Championship Series in what sets up to be a tantalizing best-of-seven series.
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| Boston Red Sox vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over - 1H | -130 |
| Under - 1H | +100 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -110 |
| Cleveland Guardians - 1I | -120 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Total - Status: OPEN | |
| Over | +100 |
| Under | -120 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| San Francisco Giants - 1H | -105 |
| Milwaukee Brewers - 1H | -125 |
