Less than a week after owner Jim Crane said the Astros were pursuing a high-end starter, the defending World Series champions traded for hard-throwing right-hander Gerrit Cole from the Pirates. The Astros will send pitchers Joe Musgrove and Michael Feliz, infielder Colin Moran and Minor League outfielder Jason Martin to the Pirates.
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| Cleveland Guardians vs New York Yankees | |
| Type: Runline - Status: SUSPENDED | |
| New York Yankees - 1I | |
| Cleveland Guardians - 1I | |
| Detroit Tigers vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers | +195 |
| San Diego Padres | -235 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -115 |
| Cincinnati Reds - 1I | -115 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |
| New York Mets vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -138 |
| New York Mets | +115 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Dodgers | -120 |
| Chicago Cubs | +100 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Houston Astros - 1H | -110 |
| Toronto Blue Jays - 1H | -120 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -195 |
| Pittsburgh Pirates | +160 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +115 |
| Arizona Diamondbacks - 1I | -150 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -145 |
| Milwaukee Brewers - 1H | +110 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -125 |
| Texas Rangers - 1H | -105 |