Mets third baseman David Wright is questionable for Opening Day due to an impingement in his right shoulder, according to general manager Sandy Alderson.
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| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians - 1H | -125 |
| Milwaukee Brewers - 1H | -105 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers - 1H | -135 |
| Boston Red Sox - 1H | +105 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | +125 |
| Philadelphia Phillies - 1I | -165 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| New York Mets | +135 |
| Pittsburgh Pirates | -160 |
| Atlanta Braves vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves | +110 |
| Washington Nationals | -130 |
| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -105 |
| Under - 1H | -125 |
| Houston Astros vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Algodoneros del Unión Laguna vs Toros de Tijuana | |
| Type: Moneyline - Status: OPEN | |
| Algodoneros del Unión Laguna | +100 |
| Toros de Tijuana | -140 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | -130 |
| Los Angeles Angels - 1H | +100 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners - 1H | +105 |
| New York Yankees - 1H | -135 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +145 |
| San Francisco Giants | -170 |
| Home Total Runs vs Away Total Runs | |
| Type: Moneyline - Status: OPEN | |
| Home Total Runs | -240 |
| Away Total Runs | +195 |
| Hokkaido Nippon-Ham Fighters vs Orix Buffaloes | |
| Type: Moneyline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | -145 |
| Orix Buffaloes | +110 |
| Tohoku Rakuten Golden Eagles vs Chiba Lotte Marines | |
| Type: Moneyline - Status: OPEN | |
| Tohoku Rakuten Golden Eagles | -115 |
| Chiba Lotte Marines | -115 |
| Hanwha Eagles vs Doosan Bears | |
| Type: Runline - Status: OPEN | |
| Hanwha Eagles | -105 |
| Doosan Bears | -125 |
| Kia Tigers vs Lotte Giants | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +105 |
| Lotte Giants | -135 |
| LG Twins vs Kiwoom Heroes | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Samsung Lions vs KT Wiz | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -130 |
| KT Wiz | +100 |
| SSG Landers vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| SSG Landers | -165 |
| NC Dinos | +125 |