The PGA Tour heads to La Quinta, Calif. this week for The American Express. Here are our best bets for the event.
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| Major Specials 2025 | |
| Type: To Win A Major 2025 - Status: OPEN | |
| Bryson DeChambeau | +500 |
| Jon Rahm | +750 |
| Collin Morikawa | +900 |
| Xander Schauffele | +900 |
| Ludvig Aberg | +1000 |
| Justin Thomas | +1100 |
| Joaquin Niemann | +1400 |
| Shane Lowry | +1600 |
| Tommy Fleetwood | +1800 |
| Tyrrell Hatton | +1800 |
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| US Open 2025 | |
| Type: Winner - Status: OPEN | |
| Scottie Scheffler | +275 |
| Bryson DeChambeau | +700 |
| Rory McIlroy | +1000 |
| Jon Rahm | +1200 |
| Xander Schauffele | +2000 |
| Ludvig Aberg | +2200 |
| Collin Morikawa | +2500 |
| Justin Thomas | +3000 |
| Joaquin Niemann | +3500 |
| Shane Lowry | +3500 |
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| The Open 2025 | |
| Type: Winner - Status: OPEN | |
| Scottie Scheffler | +400 |
| Rory McIlroy | +500 |
| Xander Schauffele | +1200 |
| Ludvig Aberg | +1400 |
| Collin Morikawa | +1600 |
| Jon Rahm | +1600 |
| Bryson DeChambeau | +2000 |
| Shane Lowry | +2500 |
| Tommy Fleetwood | +2500 |
| Tyrrell Hatton | +2500 |
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| Ryder Cup 2025 | |
| Type: Winner - Status: OPEN | |
| USA | -150 |
| Europe | +140 |
| Tie | +1200 |