On a night that ended in snow angels on the field, the Bills beat the 49ers 35-10 to continue a seven-game winning streak, improve to 10-2 and clinch a fifth straight division title.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
