Despite a 17-game winning streak in September that carried St. Louis to a wild-card berth, Mike Shildt has been fired as Cardinals manager.
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| Hiroshima Toyo Carp vs Saitama Seibu Lions | |
| Type: Runline - Status: OPEN | |
| Hiroshima Toyo Carp | -175 |
| Saitama Seibu Lions | +135 |
| Tokyo Yakult Swallows vs Fukuoka SoftBank Hawks | |
| Type: Moneyline - Status: OPEN | |
| Tokyo Yakult Swallows | +135 |
| Fukuoka SoftBank Hawks | -175 |
| Chunichi Dragons vs Chiba Lotte Marines | |
| Type: Moneyline - Status: OPEN | |
| Chunichi Dragons | -110 |
| Chiba Lotte Marines | -120 |
| Yokohama DeNa BayStars vs Hokkaido Nippon-Ham Fighters | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Hanshin Tigers vs Orix Buffaloes | |
| Type: Moneyline - Status: OPEN | |
| Hanshin Tigers | -155 |
| Orix Buffaloes | +120 |
| Yomiuri Giants vs Tohoku Rakuten Golden Eagles | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Kiwoom Heroes vs LG Twins | |
| Type: Runline - Status: OPEN | |
| Kiwoom Heroes | +110 |
| LG Twins | -145 |
| Doosan Bears vs Lotte Giants | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| Kia Tigers vs Hanwha Eagles | |
| Type: Runline - Status: OPEN | |
| Kia Tigers | -135 |
| Hanwha Eagles | +105 |
| KT Wiz vs SSG Landers | |
| Type: Moneyline - Status: OPEN | |
| KT Wiz | -200 |
| SSG Landers | +150 |
| Samsung Lions vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -145 |
| NC Dinos | +110 |
| Wei Chuan Dragons vs Uni-Lions | |
| Type: Moneyline - Status: OPEN | |
| Wei Chuan Dragons | -105 |
| Uni-Lions | -125 |
| Fubon Guardians vs CTBC Brothers | |
| Type: Total - Status: OPEN | |
| Under | -165 |
| Over | +125 |
| Rakuten Monkeys vs TSG Hawks | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Louisville vs Miami Florida | |
| Type: Moneyline - Status: OPEN | |
| Louisville | -190 |
| Miami Florida | +145 |
| North Carolina (#5) vs Arizona | |
| Type: Moneyline - Status: OPEN | |
| North Carolina (#5) | -330 |
| Arizona | +235 |
| Murray State vs Duke | |
| Type: Moneyline - Status: OPEN | |
| Murray State | +225 |
| Duke | -310 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1I | -130 |
| Philadelphia Phillies - 1I | +100 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Total - Status: OPEN | |
| Under - 1H | -120 |
| Over - 1H | -110 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Under - 1H | -120 |
| Over - 1H | -110 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1I | -115 |
| Los Angeles Dodgers - 1I | -115 |
| Tennessee (#14) vs Arkansas (#3) | |
| Type: Moneyline - Status: OPEN | |
| Tennessee (#14) | -130 |
| Arkansas (#3) | +100 |
| UTSA vs UCLA (#15) | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Runline - Status: SUSPENDED | |
| San Francisco Giants - 1I | |
| Atlanta Braves - 1I | |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Moneyline - Status: SUSPENDED | |
| Los Angeles Angels - 1I | -110 |
| Seattle Mariners - 1I | -120 |
| West Virginia vs LSU (#6) | |
| Type: Runline - Status: OPEN | |
| West Virginia | -110 |
| LSU (#6) | -120 |