The Red Sox advanced to the ALCS with the help of two players who entered the season wanting to prove their worth: Kiké Hernandez, who delivered a walk-off sacrifice fly, and reliever Garrett Whitlock, who earned the win with two scoreless innings.
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| Tohoku Rakuten Golden Eagles vs Fukuoka SoftBank Hawks | |
| Type: Runline - Status: OPEN | |
| Tohoku Rakuten Golden Eagles | -200 |
| Fukuoka SoftBank Hawks | +150 |
| Saitama Seibu Lions vs Orix Buffaloes | |
| Type: Total - Status: OPEN | |
| Over | -125 |
| Under | -105 |
| Hanshin Tigers vs Yomiuri Giants | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Hokkaido Nippon-Ham Fighters vs Chiba Lotte Marines | |
| Type: Runline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +130 |
| Chiba Lotte Marines | -170 |
| Chunichi Dragons vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Chunichi Dragons | -145 |
| Tokyo Yakult Swallows | +110 |
| Yokohama DeNa BayStars vs Hiroshima Toyo Carp | |
| Type: Runline - Status: OPEN | |
| Yokohama DeNa BayStars | +135 |
| Hiroshima Toyo Carp | -175 |
| Doosan Bears vs Lotte Giants | |
| Type: Moneyline - Status: OPEN | |
| Doosan Bears | +105 |
| Lotte Giants | -135 |
| Hanwha Eagles vs KT Wiz | |
| Type: Runline - Status: OPEN | |
| KT Wiz | +125 |
| Hanwha Eagles | -165 |
| Kia Tigers vs LG Twins | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| SSG Landers vs Kiwoom Heroes | |
| Type: Moneyline - Status: OPEN | |
| Kiwoom Heroes | +125 |
| SSG Landers | -165 |
| Samsung Lions vs NC Dinos | |
| Type: Moneyline - Status: OPEN | |
| Samsung Lions | -135 |
| NC Dinos | +105 |
| Chicago Cubs vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Chicago Cubs | -135 |
| Philadelphia Phillies | +113 |
| Detroit Tigers vs Baltimore Orioles | |
| Type: Runline - Status: SUSPENDED | |
| Baltimore Orioles - 1I | |
| Detroit Tigers - 1I | |
| New York Yankees vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Toronto Blue Jays - 1I | +110 |
| New York Yankees - 1I | -145 |
| Cleveland Guardians vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | +145 |
| Cleveland Guardians | -170 |
| Kansas City Royals vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Houston Astros | +135 |
| Kansas City Royals | -160 |
| St. Louis Cardinals vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| St. Louis Cardinals | +160 |
| Milwaukee Brewers | -185 |
| Colorado Rockies vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -138 |
| Colorado Rockies | +115 |
| Seattle Mariners vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Seattle Mariners | -250 |
| Miami Marlins | +205 |
| Athletics vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| San Francisco Giants vs Texas Rangers | |
| Type: Total - Status: SUSPENDED | |
| Over - 1I | |
| Under - 1I | |