The Washington Nationals will be down five players and a staff member for Opening Day after a player tested positive for COVID-19, general manager Mike Rizzo said Wednesday.
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| Miami Marlins vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins | +169 |
| Los Angeles Dodgers | -208 |
| Washington Nationals vs Cleveland Guardians | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| New York Yankees vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Over - 1I | +230 |
| Under - 1I | -320 |
| Atlanta Braves vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves - 1H | -105 |
| Cincinnati Reds - 1H | -125 |
| Milwaukee Brewers vs Houston Astros | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -125 |
| Houston Astros - 1I | -105 |
| Kansas City Royals vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | -215 |
| Chicago White Sox - 1H | +160 |
| Chicago Cubs vs San Francisco Giants | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| St. Louis Cardinals vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -120 |
| Arizona Diamondbacks vs New York Mets | |
| Type: Total - Status: OPEN | |
| Over | -105 |
| Under | -115 |
| Athletics vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over - 1I | +200 |
| Under - 1I | -275 |