The 49ers have promoted Mike McDaniel to offensive coordinator and DeMeco Ryans to defensive coordinator after Robert Saleh was hired as coach of the Jets and took Mike LaFleur with him to be his OC.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |