The 49ers will play their home games in Weeks 13 and 14 in the Cardinals’ stadium after Santa Clara County’s three-week ban on contact sports due to increased COVID-19 cases.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |