The Dodgers, who finished off the Rays on Tuesday in six games, head into the offseason as +400 favorites to win the 2021 World Series, ahead of the Yankees (+650) and Padres (+850).
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| Atlanta Braves vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +135 |
| Atlanta Braves - 1H | -180 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees | -155 |
| Cleveland Guardians | +130 |
| Detroit Tigers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | +125 |
| Detroit Tigers - 1H | -165 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Miami Marlins | +160 |
| Cincinnati Reds | -185 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Over - 1I | +250 |
| Under - 1I | -360 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Seattle Mariners - 1H | -120 |
| Boston Red Sox - 1H | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1I | -110 |
| Baltimore Orioles - 1I | -120 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +205 |
| Minnesota Twins | -250 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Runline - Status: OPEN | |
| Houston Astros - 1H | +105 |
| Toronto Blue Jays - 1H | -135 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +115 |
| Los Angeles Angels - 1H | -150 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +110 |
| Arizona Diamondbacks - 1I | -145 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -120 |
| Over - 1H | -110 |
| Athletics vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -110 |
| Over - 1H | -120 |