Just as the 49ers’ offense was rounding into form, the team has lost wide receiver Deebo Samuel (hamstring strain) and running back Jeff Wilson Jr. (high ankle sprain) for multiple weeks due to injury.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
