The Steelers sacked Baker Mayfield four times and intercepted him twice in a 38-7 win that gave them just the second 5-0 start in franchise history and first since 1978.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
