Astros slugger Yordan Alvarez, who hit .313 with 27 home runs and 78 RBIs in 87 games en route to being the AL Rookie of the Year last season, has been activated off the injured list.
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| Cleveland Guardians vs New York Yankees | |
| Type: Runline - Status: SUSPENDED | |
| New York Yankees - 1I | |
| Cleveland Guardians - 1I | |
| Detroit Tigers vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers | +180 |
| San Diego Padres | -220 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -120 |
| Cincinnati Reds - 1I | -110 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Total - Status: OPEN | |
| Over - 1I | +200 |
| Under - 1I | -275 |
| New York Mets vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -135 |
| New York Mets | +113 |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| St. Louis Cardinals | -170 |
| Atlanta Braves | +145 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Houston Astros - 1H | -105 |
| Toronto Blue Jays - 1H | -125 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -199 |
| Pittsburgh Pirates | +164 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +115 |
| Arizona Diamondbacks - 1I | -150 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -145 |
| Milwaukee Brewers - 1H | +110 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -115 |
| Texas Rangers - 1H | -115 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | -135 |
| Hanshin Tigers | +105 |
| Chiba Lotte Marines vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Chiba Lotte Marines | -190 |
| Saitama Seibu Lions | +145 |
| Fukuoka SoftBank Hawks vs Orix Buffaloes | |
| Type: Runline - Status: OPEN | |
| Fukuoka SoftBank Hawks | +190 |
| Orix Buffaloes | -260 |
| Hokkaido Nippon-Ham Fighters vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +185 |
| Tohoku Rakuten Golden Eagles | -250 |
| Hiroshima Toyo Carp vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Hiroshima Toyo Carp | -155 |
| Tokyo Yakult Swallows | +120 |
| Yomiuri Giants vs Chunichi Dragons | |
| Type: Runline - Status: OPEN | |
| Yomiuri Giants | +125 |
| Chunichi Dragons | -165 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| KT Wiz vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| LG Twins vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Moneyline - Status: OPEN | |
| Lotte Giants | -125 |
| Hanwha Eagles | -105 |
| Samsung Lions vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +115 |
| Samsung Lions | -150 |
