Niners rookie defensive end Nick Bosa and veteran running back Tevin Coleman stole the show on a day when San Francisco moved to 7-0 for the first time since 1990 and only the second time in franchise history.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |