Tennessee quarterback Marcus Mariota has been replaced by backup Ryan Tannehill late in the third quarter with the offense struggling. With Mariota running the show, the Titans managed just six first downs and 88 total yards trailing Denver 13-0. Mariota also was intercepted twice for his first turnovers
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |
