San Francisco is surprisingly 4-0 and sitting atop the NFC West. Jimmy Garoppolo takes the Niners on the road to face the defending conference champs.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |