Frank Gore ran for a 1-yard touchdown with 1:50 remaining to give the Buffalo Bills a 21-17 lead over Cincinnati. For a third straight week, the Detroit Lions are trying to protect a lead late in the fourth quarter. Detroit leads Philadelphia 27-24 and stopped the Eagles on fourth down with 2:18 remaining
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| Detroit Lions vs Los Angeles Chargers | |
| Type: Point Spread - Status: OPEN | |
| Detroit Lions | -105 |
| Los Angeles Chargers | -115 |
| Philadelphia Eagles vs Dallas Cowboys | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |