Right-hander Gerrit Cole will offer a familiar face on the mound for the Astros on Wednesday, a relative change of pace after Houston debuted two recently acquired right-handed pitchers on Saturday (Aaron Sanchez) and Tuesday (Zack Greinke). With all the change brought about last week at the trade deadline
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| Cleveland Guardians vs New York Yankees | |
| Type: Runline - Status: SUSPENDED | |
| New York Yankees - 1I | |
| Cleveland Guardians - 1I | |
| Detroit Tigers vs San Diego Padres | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers | +180 |
| San Diego Padres | -220 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Moneyline - Status: OPEN | |
| Miami Marlins - 1I | -120 |
| Cincinnati Reds - 1I | -110 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Total - Status: OPEN | |
| Over - 1I | +200 |
| Under - 1I | -275 |
| New York Mets vs Philadelphia Phillies | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -135 |
| New York Mets | +113 |
| Atlanta Braves vs St. Louis Cardinals | |
| Type: Runline - Status: OPEN | |
| St. Louis Cardinals | -170 |
| Atlanta Braves | +145 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Houston Astros - 1H | -105 |
| Toronto Blue Jays - 1H | -125 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels | -199 |
| Pittsburgh Pirates | +164 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +115 |
| Arizona Diamondbacks - 1I | -150 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Moneyline - Status: OPEN | |
| San Francisco Giants - 1H | -145 |
| Milwaukee Brewers - 1H | +110 |
| Athletics vs Texas Rangers | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -115 |
| Texas Rangers - 1H | -115 |
| Yokohama DeNa BayStars vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yokohama DeNa BayStars | -135 |
| Hanshin Tigers | +105 |
| Chiba Lotte Marines vs Saitama Seibu Lions | |
| Type: Moneyline - Status: OPEN | |
| Chiba Lotte Marines | -190 |
| Saitama Seibu Lions | +145 |
| Fukuoka SoftBank Hawks vs Orix Buffaloes | |
| Type: Runline - Status: OPEN | |
| Fukuoka SoftBank Hawks | +190 |
| Orix Buffaloes | -260 |
| Hokkaido Nippon-Ham Fighters vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Hokkaido Nippon-Ham Fighters | +185 |
| Tohoku Rakuten Golden Eagles | -250 |
| Hiroshima Toyo Carp vs Tokyo Yakult Swallows | |
| Type: Moneyline - Status: OPEN | |
| Hiroshima Toyo Carp | -155 |
| Tokyo Yakult Swallows | +120 |
| Yomiuri Giants vs Chunichi Dragons | |
| Type: Runline - Status: OPEN | |
| Yomiuri Giants | +125 |
| Chunichi Dragons | -165 |
| Kiwoom Heroes vs Doosan Bears | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -120 |
| KT Wiz vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| LG Twins vs NC Dinos | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Lotte Giants vs Hanwha Eagles | |
| Type: Moneyline - Status: OPEN | |
| Lotte Giants | -125 |
| Hanwha Eagles | -105 |
| Samsung Lions vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kia Tigers | +115 |
| Samsung Lions | -150 |