Even in an age of “openers” and extended bullpens, there is an undeniable cache to being a team’s Opening Day starter. It’s a legitimate honor.
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| Atlanta Braves vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +130 |
| Atlanta Braves - 1H | -170 |
| Cleveland Guardians vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees | -165 |
| Cleveland Guardians | +139 |
| Detroit Tigers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1H | +125 |
| Detroit Tigers - 1H | -165 |
| Miami Marlins vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Miami Marlins | +170 |
| Cincinnati Reds | -200 |
| New York Mets vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Over - 1I | +250 |
| Under - 1I | -360 |
| Boston Red Sox vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Seattle Mariners - 1H | -115 |
| Boston Red Sox - 1H | -115 |
| Washington Nationals vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Washington Nationals - 1I | -110 |
| Baltimore Orioles - 1I | -120 |
| Chicago Cubs vs Los Angeles Dodgers | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -105 |
| Minnesota Twins vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +210 |
| Minnesota Twins | -260 |
| Kansas City Royals vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -120 |
| Under - 1H | -110 |
| Houston Astros vs Toronto Blue Jays | |
| Type: Runline - Status: OPEN | |
| Houston Astros - 1H | +110 |
| Toronto Blue Jays - 1H | -145 |
| Los Angeles Angels vs Pittsburgh Pirates | |
| Type: Moneyline - Status: OPEN | |
| Pittsburgh Pirates - 1H | +105 |
| Los Angeles Angels - 1H | -135 |
| Arizona Diamondbacks vs Tampa Bay Rays | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1I | +110 |
| Arizona Diamondbacks - 1I | -145 |
| San Francisco Giants vs Milwaukee Brewers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Athletics vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under - 1H | -105 |
| Over - 1H | -125 |