The Cubs had scored one or fewer runs against the stingy Pirates in their previous six meetings, but Jason Heyward finally broke through in the first inning on Wednesday night with a much-needed home run.
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| Miami Florida vs Louisville | |
| Type: Moneyline - Status: OPEN | |
| Miami Florida | +130 |
| Louisville | -170 |
| Arizona vs North Carolina (#5) | |
| Type: Runline - Status: OPEN | |
| Arizona | -120 |
| North Carolina (#5) | -110 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -135 |
| Murray State | +105 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Detroit Tigers - 1I | -120 |
| Chicago Cubs - 1I | -110 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -350 |
| West Virginia | +240 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Under | +100 |
| Over | -120 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +150 |
| Los Angeles Dodgers - 1H | -200 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under - 1H | -130 |
| Over - 1H | +100 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +129 |
| Kansas City Royals | -154 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | +100 |
| Miami Marlins - 1H | -130 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Cleveland Guardians vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians | -165 |
| Houston Astros | +140 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -360 |
| Over - 1I | +250 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Florida State (#9) vs Oregon State (#8) | |
| Type: Moneyline - Status: OPEN | |
| Florida State (#9) | -160 |
| Oregon State (#8) | +120 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels - 1H | +125 |
| Seattle Mariners - 1H | -165 |
| Colorado Rockies vs New York Mets | |
| Type: Moneyline - Status: OPEN | |
| Colorado Rockies - 1H | +200 |
| New York Mets - 1H | -275 |
| Athletics vs Baltimore Orioles | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | -145 |
| Baltimore Orioles - 1H | +110 |