Cole Hamels picked up the win in his Cubs debut, collected his first hit since 2016, and even got his first at-bat before he took the mound. Chicago gave the lefty a four-run cushion in the first inning, and Willson Contreras added a two-run homer in the eighth to seal the win, splitting the two-game set. Pirates starter Nick Kingham lasted just one inning, while Hamels went five, allowing one unearned run on three hits and striking out nine.
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| Miami Florida vs Louisville | |
| Type: Moneyline - Status: OPEN | |
| Miami Florida | +130 |
| Louisville | -170 |
| Arizona vs North Carolina (#5) | |
| Type: Runline - Status: OPEN | |
| Arizona | -120 |
| North Carolina (#5) | -110 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -135 |
| Murray State | +105 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Moneyline - Status: OPEN | |
| Detroit Tigers - 1I | -120 |
| Chicago Cubs - 1I | -110 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -350 |
| West Virginia | +240 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | +150 |
| Los Angeles Dodgers - 1H | -200 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under - 1H | -130 |
| Over - 1H | +100 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Chicago White Sox | +129 |
| Kansas City Royals | -154 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | -105 |
| Miami Marlins - 1H | -125 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Cleveland Guardians vs Houston Astros | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians | -150 |
| Houston Astros | +130 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | -110 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -360 |
| Over - 1I | +250 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Florida State (#9) vs Oregon State (#8) | |
| Type: Moneyline - Status: OPEN | |
| Florida State (#9) | -160 |
| Oregon State (#8) | +120 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Moneyline - Status: OPEN | |
| Los Angeles Angels - 1H | +125 |
| Seattle Mariners - 1H | -165 |
| Colorado Rockies vs New York Mets | |
| Type: Moneyline - Status: OPEN | |
| Colorado Rockies - 1H | +200 |
| New York Mets - 1H | -275 |
| Athletics vs Baltimore Orioles | |
| Type: Runline - Status: OPEN | |
| Athletics - 1H | +110 |
| Baltimore Orioles - 1H | -145 |
