Not every rookie will leave his mark on baseball like Aaron Judge and Cody Bellinger did a year ago, but each club has a prospect or prospects who should crack its big league roster in 2018. Below are MLB Pipeline’s choices for the rookies who will make the biggest impact on each team in each division.
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| Washington Nationals vs Cleveland Guardians | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| Atlanta Braves vs Cincinnati Reds | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves - 1H | +110 |
| Cincinnati Reds - 1H | -145 |
| New York Yankees vs San Diego Padres | |
| Type: Total - Status: OPEN | |
| Over - 1I | +230 |
| Under - 1I | -320 |
| Milwaukee Brewers vs Houston Astros | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -120 |
| Houston Astros - 1I | -110 |
| Kansas City Royals vs Chicago White Sox | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | -210 |
| Chicago White Sox - 1H | +155 |
| Chicago Cubs vs San Francisco Giants | |
| Type: Total - Status: OPEN | |
| Under - 1I | -340 |
| Over - 1I | +240 |
| St. Louis Cardinals vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Arizona Diamondbacks vs New York Mets | |
| Type: Total - Status: OPEN | |
| Over | -110 |
| Under | -110 |
| Athletics vs Seattle Mariners | |
| Type: Total - Status: OPEN | |
| Over - 1I | +200 |
| Under - 1I | -275 |
| Hawaii vs Oregon State (#7) | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Tokyo Yakult Swallows vs Hiroshima Toyo Carp | |
| Type: Total - Status: OPEN | |
| Under | -125 |
| Over | -105 |
| Chunichi Dragons vs Yokohama DeNa BayStars | |
| Type: Runline - Status: OPEN | |
| Chunichi Dragons | -185 |
| Yokohama DeNa BayStars | +140 |
| Orix Buffaloes vs Hokkaido Nippon-Ham Fighters | |
| Type: Moneyline - Status: OPEN | |
| Orix Buffaloes | +105 |
| Hokkaido Nippon-Ham Fighters | -135 |
| Chiba Lotte Marines vs Tohoku Rakuten Golden Eagles | |
| Type: Runline - Status: OPEN | |
| Chiba Lotte Marines | +140 |
| Tohoku Rakuten Golden Eagles | -185 |
| Saitama Seibu Lions vs Fukuoka SoftBank Hawks | |
| Type: Runline - Status: OPEN | |
| Saitama Seibu Lions | -135 |
| Fukuoka SoftBank Hawks | +105 |
| Doosan Bears vs LG Twins | |
| Type: Runline - Status: OPEN | |
| Doosan Bears | +100 |
| LG Twins | -130 |
| Hanwha Eagles vs Samsung Lions | |
| Type: Runline - Status: OPEN | |
| Samsung Lions | -260 |
| Hanwha Eagles | +190 |
| Kiwoom Heroes vs Kia Tigers | |
| Type: Moneyline - Status: OPEN | |
| Kiwoom Heroes | +155 |
| Kia Tigers | -205 |
| Lotte Giants vs SSG Landers | |
| Type: Total - Status: OPEN | |
| Over | -115 |
| Under | -115 |
| KT Wiz vs NC Dinos | |
| Type: Runline - Status: OPEN | |
| KT Wiz | +125 |
| NC Dinos | -165 |
| Yomiuri Giants vs Hanshin Tigers | |
| Type: Moneyline - Status: OPEN | |
| Yomiuri Giants | +125 |
| Hanshin Tigers | -165 |
| TSG Hawks vs Wei Chuan Dragons | |
| Type: Moneyline - Status: OPEN | |
| TSG Hawks | +130 |
| Wei Chuan Dragons | -170 |
| Fubon Guardians vs Rakuten Monkeys | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |