As soon as the Astros closed out a stirring seven-game World Series by bringing home the first title in franchise history, the questions began. Can they do it again next year and become the first repeat World Series winner since the Yankees did it in 1999 and 2000?
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| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Milwaukee Brewers - 1H | -130 |
| Cleveland Guardians - 1H | +100 |
| Baltimore Orioles vs Minnesota Twins | |
| Type: Runline - Status: OPEN | |
| Minnesota Twins | -180 |
| Baltimore Orioles | +155 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: OPEN | |
| Boston Red Sox | +150 |
| Detroit Tigers | -175 |
| Cincinnati Reds vs Chicago White Sox | |
| Type: Total - Status: OPEN | |
| Under - 1I | -290 |
| Over - 1I | +210 |
| Philadelphia Phillies vs St. Louis Cardinals | |
| Type: Moneyline - Status: OPEN | |
| Philadelphia Phillies | -159 |
| St. Louis Cardinals | +133 |
| Toronto Blue Jays vs Tampa Bay Rays | |
| Type: Runline - Status: OPEN | |
| Tampa Bay Rays - 1H | -150 |
| Toronto Blue Jays - 1H | +115 |
| New York Mets vs Pittsburgh Pirates | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Atlanta Braves vs Washington Nationals | |
| Type: Total - Status: OPEN | |
| Over - 1H | +100 |
| Under - 1H | -130 |
| Chicago Cubs vs Miami Marlins | |
| Type: Runline - Status: OPEN | |
| Chicago Cubs | -115 |
| Miami Marlins | -105 |
| Texas Rangers vs Colorado Rockies | |
| Type: Runline - Status: OPEN | |
| Texas Rangers | -110 |
| Colorado Rockies | -110 |
| Houston Astros vs Kansas City Royals | |
| Type: Moneyline - Status: OPEN | |
| Kansas City Royals - 1H | +110 |
| Houston Astros - 1H | -145 |
| Seattle Mariners vs New York Yankees | |
| Type: Moneyline - Status: OPEN | |
| New York Yankees - 1I | -115 |
| Seattle Mariners - 1I | -115 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Moneyline - Status: OPEN | |
| San Diego Padres - 1I | -170 |
| Los Angeles Angels - 1I | +130 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | +155 |
| San Francisco Giants | -180 |
| Los Angeles Dodgers vs Athletics | |
| Type: Moneyline - Status: OPEN | |
| Athletics | +180 |
| Los Angeles Dodgers | -220 |