Jacksonville got its first season-opening win since 2011 thanks to a pair of players making their Jaguars debuts. Fourth overall pick Leonard Fournette ran for 100 yards and a touchdown and free-agent acquisition Calais Campbell had four of Jacksonville’s franchise-record 10 sacks in a 29-7 win
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |