Phil Hughes pitched six strong innings for his first win in almost a year and the Minnesota Twins beat the Chicago White Sox 3-1 on Friday night for their first 4-0 start since 1987. Miguel Sano hit an RBI go-ahead double in the sixth, and Chris Gimenez added an RBI double in the seventh for the Twins, who led the majors with 103 losses last season after opening 0-9. Tyler Duffey pitched two scoreless innings of relief, and Brandon Kintzler pitched a scoreless ninth for his second save.
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| Shandong Blue Whale vs Guangdong Leopard | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -125 |
| Cleveland Guardians vs Milwaukee Brewers | |
| Type: Runline - Status: OPEN | |
| Cleveland Guardians - 1H | -125 |
| Milwaukee Brewers - 1H | -105 |
| Detroit Tigers vs Boston Red Sox | |
| Type: Runline - Status: SUSPENDED | |
| Boston Red Sox - 1I | |
| Detroit Tigers - 1I | |
| New York Mets vs Pittsburgh Pirates | |
| Type: Runline - Status: OPEN | |
| New York Mets | +165 |
| Pittsburgh Pirates | -195 |
| Atlanta Braves vs Washington Nationals | |
| Type: Runline - Status: OPEN | |
| Atlanta Braves | +120 |
| Washington Nationals | -140 |
| Chicago Cubs vs Miami Marlins | |
| Type: Total - Status: SUSPENDED | |
| Over | |
| Under | |
| Texas Rangers vs Colorado Rockies | |
| Type: Total - Status: OPEN | |
| Over - 1H | -110 |
| Under - 1H | -120 |
| San Diego Padres vs Los Angeles Angels | |
| Type: Runline - Status: OPEN | |
| San Diego Padres - 1H | +105 |
| Los Angeles Angels - 1H | -135 |
| San Francisco Giants vs Arizona Diamondbacks | |
| Type: Runline - Status: OPEN | |
| Arizona Diamondbacks | -225 |
| San Francisco Giants | +185 |