Once again, the Cleveland Indians are minus a significant piece. Second baseman Jason Kipnis is likely to miss opening day because of a sore right shoulder, an injury that could cause the AL champions to re-shape their infield for the start of this season. Kipnis has been slowed by inflammation in his shoulder throughout training camp and the Indians are going to shut him down for two weeks to see how it responds.
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| North Carolina (#5) vs Arizona | |
| Type: Runline - Status: OPEN | |
| North Carolina (#5) | -115 |
| Arizona | -115 |
| Tampa Bay Rays vs Miami Marlins | |
| Type: Moneyline - Status: OPEN | |
| Tampa Bay Rays - 1H | -180 |
| Miami Marlins - 1H | +135 |
| Louisville vs Miami Florida | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Oregon State (#8) vs Florida State (#9) | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -120 |
| Pittsburgh Pirates vs Philadelphia Phillies | |
| Type: Runline - Status: OPEN | |
| Pittsburgh Pirates | -135 |
| Philadelphia Phillies | +115 |
| Washington Nationals vs Texas Rangers | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -105 |
| New York Yankees vs Boston Red Sox | |
| Type: Total - Status: OPEN | |
| Under - 1H | -125 |
| Over - 1H | -105 |
| Detroit Tigers vs Chicago Cubs | |
| Type: Runline - Status: OPEN | |
| Detroit Tigers - 1H | -135 |
| Chicago Cubs - 1H | +105 |
| Cincinnati Reds vs Arizona Diamondbacks | |
| Type: Moneyline - Status: OPEN | |
| Cincinnati Reds | -110 |
| Arizona Diamondbacks | -110 |
| Cleveland Guardians vs Houston Astros | |
| Type: Total - Status: OPEN | |
| Under | -120 |
| Over | +100 |
| Chicago White Sox vs Kansas City Royals | |
| Type: Total - Status: OPEN | |
| Under | -105 |
| Over | -115 |
| Milwaukee Brewers vs San Diego Padres | |
| Type: Moneyline - Status: OPEN | |
| Milwaukee Brewers - 1I | -145 |
| San Diego Padres - 1I | +110 |
| Minnesota Twins vs Toronto Blue Jays | |
| Type: Moneyline - Status: OPEN | |
| Minnesota Twins | -155 |
| Toronto Blue Jays | +130 |
| St. Louis Cardinals vs Los Angeles Dodgers | |
| Type: Moneyline - Status: OPEN | |
| St. Louis Cardinals - 1H | -150 |
| Los Angeles Dodgers - 1H | +115 |
| Colorado Rockies vs New York Mets | |
| Type: Runline - Status: OPEN | |
| Colorado Rockies - 1H | +115 |
| New York Mets - 1H | -150 |
| Auburn (#4) vs Coastal Carolina (#13) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| Los Angeles Angels vs Seattle Mariners | |
| Type: Runline - Status: OPEN | |
| Los Angeles Angels - 1H | -125 |
| Seattle Mariners - 1H | -105 |
| Athletics vs Baltimore Orioles | |
| Type: Moneyline - Status: OPEN | |
| Athletics - 1H | +105 |
| Baltimore Orioles - 1H | -135 |
| San Francisco Giants vs Atlanta Braves | |
| Type: Total - Status: OPEN | |
| Under | -110 |
| Over | -110 |
| Duke vs Murray State | |
| Type: Runline - Status: OPEN | |
| Duke | -130 |
| Murray State | +100 |
| LSU (#6) vs West Virginia | |
| Type: Moneyline - Status: OPEN | |
| LSU (#6) | -330 |
| West Virginia | +235 |
| Arkansas (#3) vs Tennessee (#14) | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
| UCLA (#15) vs UTSA | |
| Type: Total - Status: OPEN | |
| Under | -115 |
| Over | -115 |
