. – Clemson destroyed Ohio State in a dominating 31-0 victory on Saturday to set up a rematch against Alabama in the College Football national championship game. Deshaun Watson passed for 259 yards and a touchdown and ran for two scores as Clemson cruised. Watson scored on a 1-yard run in the first quarter and threw a 30-yard touchdown pass late the second quarter to give No. 2 Clemson (13-1) a 17-0 halftime lead.
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| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| NFC Conference | -105 |
| AFC Conference | -115 |
| AFC Conference vs NFC Conference | |
| Type: Moneyline - Status: OPEN | |
| AFC Conference | -115 |
| NFC Conference | -105 |